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BL3301   Protein Structure and Function

Academic year(s): 2019-2020

Key information

SCOTCAT credits : 20

ECTS credits : 10

Level : SCQF Level 9

Semester: 1

Planned timetable: Lectures: 9.00 am Mon, Tue and Wed Practicals: to be arranged.

This module builds an understanding of more advanced aspects of protein structure and enzymology. The module begins by considering the protein-folding problem. The energetics of protein folding and the dependence of structure on sequence are examined. Protein folding diseases like spongiform encephalopathies are used as examples to highlight the significance of protein folding. The molecular basis of prion diseases is discussed in detail. The second part of the module focuses on the mechanisms of enzymes. This in turn leads into the phenomena of allosteric regulation, signalling cascades and transporter systems and is followed by a consideration of enzymes as pharmacological targets. The third part of the module introduces the major techniques for protein structure determination that are at the heart of modern biochemistry, molecular biology and drug discovery. Strategies for obtaining three-dimensional images of macromolecules by electron microscopy, X-ray crystallography and nuclear magnetic resonance are discussed. The laboratory course associated with this module introduces the fundamentals of safe laboratory practice. It provides grounding in the basic laboratory techniques, including associated calculations, as well as those associated with the study of proteins and enzymes.

Learning and teaching methods and delivery

Weekly contact: 3 x 1-hour lectures (x 10 weeks) and 3 x 8-hour practicals, and 1 x 4-hour practical, split over several days, during the semester.

Scheduled learning hours: 62

Guided independent study hours: 138

Assessment pattern

As used by St Andrews: 3-hour Written Examination = 66%, Coursework = 34%

As defined by QAA
Written examinations : 66%
Practical examinations : 0%
Coursework: 34%

Re-assessment: 3-hour Written Examination = 66%, Existing Coursework = 34%

Personnel

Module coordinator: Dr U Schwarz-Linek
Module teaching staff: Team taught